Research group
Molecular Synthesis
Position
Researcher
Ivo E. Sampaio-Dias obtained his B.Sc. (2011) and M.Sc. (2014) in Biochemistry and a Ph.D. in Sustainable Chemistry (2018) at the University of Porto in partnership with the University of Santiago de Compostela. Dr. Sampaio-Dias is an Integrated researcher at REQUIMTE (CEEC contract) and an Invited Assistant Professor at the Faculty of Sciences, University of Porto. His fields of expertise include Organic and Medicinal Chemistry. In 2022, Dr. Sampaio-Dias secured a research grant funded by FCT, being PI of the “DynaPro” project (DOI: 10.54499/2022.01175.PTDC) for the development of Melanostatin (MIF-1) neuropeptide derivatives for application in Parkinson's disease. He has participated as a researcher in the FCT-funded project "SilaSeco" for the molecular docking and preparation of anti-tumoral vitamin D derivatives, being co-inventor of a PCT patent. Dr. Sampaio-Dias has published 23 high-impact research papers and has supervised 51 students: 3 Ph.D., 5 M.Sc., 15 B.Sc. (1 ongoing), and 28 undergraduate students. IESD has also participated as a member of academic degrees of a total of 21 students (including 3 Ph.D. and 9 M.Sc.). IESD has 33 oral communications (including an invited keynote) and 58 posters, 8 of them distinguished (6 in the field of Melanostatin research). IESD received several awards, including the IACOBUS Research Papers and Patents Awards, and serves as Associate Editorial Board Member of the Current Medicinal Chemistry journal. Currently, his research topics include the development of new synthetic methodologies in peptide chemistry and the discovery of peptide-based allosteric modulators targeting GPCRs with applications in CNS disorders.
Representative Publications
Mechanistic insights for the transprotection of tertiary amines with Boc(2)O via charged carbamates: access to both enantiomers of 2-azanorbornane-3-exo-carboxylic acids
10.1039/c9qo00957d
Synthesis, Pharmacological, and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R
10.1021/acschemneuro.9b00259
A Strategy for The Assembly of Glypromate® and Structure-Related Analogues by Tandem Sequential Peptide Coupling
10.1039/d0gc00143k
Discovery of New Potent Positive Allosteric Modulators of Dopamine D2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide
10.1021/acs.jmedchem.1c00252
Synthesis, Pharmacological, and Biological Evaluation of 2-FuroylBased MIF-1 Peptidomimetics and the Development of a GeneralPurpose Model for Allosteric Modulators (ALLOPTML)
10.1021/acschemneuro.0c00687
Design, Synthesis, and Biological Evaluation of Hybrid Glypromate Analogues Using 2-Azanorbornane as a Prolyl and Pipecolyl Surrogate
10.1021/acschemneuro.1c00339
Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors
10.1021/acsmedchemlett.3c00264
