Jorge graduated in Pharmaceutical Sciences (PharmD, U.Porto, 2000) with 1st class honours (Eng. António de Almeida Foundation Award). He earned his PhD in Pharmacology (U.Porto, 2006) and his main international experience includes the Sillero Lab (UAM, Spain), Nicholls Lab (Buck, USA), Lightowlers Lab (NCL, UK) and Duchen Lab (UCL, UK). He is currently an Assistant professor at FFUP (U.Porto), having established the Neuroscience unit, and coordinated Pharmacology and Physiology units. Jorge’s main research interests are neurodegenerative disorders (esp. Huntington’s disease), and the target validation and protective mechanisms of small molecule modulators of mitochondria, epigenetics and proteostasis (www.mitoneuro.com).
Representative Publications
Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease
10.1016/j.phrs.2015.11.024
HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons
10.1016/j.bbadis.2015.08.012
The interplay between redox signalling and proteostasis in neurodegeneration: In vivo effects of a mitochondria-targeted antioxidant in Huntington's disease mice
10.1016/j.freeradbiomed.2019.11.021
Allosteric activation of Hsp70 reduces mutant huntingtin levels, the clustering of N-terminal fragments, and their nuclear accumulation
10.1016/j.lfs.2021.120009
The PERKs of mitochondria protection during stress: insights for PERK modulation in neurodegenerative and metabolic diseases
10.1111/brv.12860
Automated analysis of activity, sleep, and rhythmic behaviour in various animal species with the Rtivity software
10.1038/s41598-022-08195-z
-20210222_162436.jpg)
