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(Chemical) Bonding is what makes life possible

Maria Paula M. Marques

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pmc@ci.uc.pt
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Research group
Chemistry and Bioactivity

Position
Academic Staff

ORCID0000-0002-8391-0055
Ciência ID6B14-8AE7-9596
Maria Paula M. Marques, FRSC
University of Coimbra (Portugal), “Molecular Physical-Chemistry” R&D Unit
Dep. Life Sciences, Fac. Science and Technology, Univ. Coimbra, 3000-456 Coimbra

Maria Paula M. Marques (ORCID ID: 0000-0002-8391-0055) – MSc in Physical-Chemistry (1987), PhD in Biochemistry (1995), habilitation in Biosciences (2018) / University of Coimbra (Portugal).
Associate professor at the Dep. Life Sciences/Univ. Coimbra, assistant-coordinator of the R&D Group “Molecular Physical-Chemistry”.
over 220 scientific papers, 9 book chapters and co-edited 3 books (H-index=38, ca. 5900 citations). Fellow of the Royal Society of Chemistry. Member of: European Spallation Source Science Advisory Committee; ISIS User´s Committee; Clinical Infrared/Raman Spectroscopy for Medical Diagnosis; Portuguese Societies of Chemistry, Biochemistry, Pharmacology; Biophotonics World; International Society for Plant Spectroscopy. President of “Neutron and Muon Users in Portugal”. Portuguese delegate at the European Neutron Scattering Association. ISIS Neutron & Muon Source Impact Award 2019/Public Engagement & Society.
Research on: design of Pt/Pd-anticancer agents; cancer diagnosis by vibrational spectroscopy; characterisation of burned human bones; food products/nutraceuticals. Vibrational spectroscopy is the main methodology, including synchrotron-based (FTIR and EXAFS) and neutron scattering techniques.

Representative Publications

Novel Insights into Mice Multi-Organ Metabolism upon Exposure to a Potential Anticancer Pd(II)-Agent
10.3390/metabo11020114
Intracellular water-an overlooked drug target? Cisplatin impact in cancer cells probed by neutrons
10.1039/c6cp05198g
Role of intracellular water in the normal-to-cancer transition in human cells-insights from quasi-elastic neutron scattering
10.1063/4.0000021
Chemotherapeutic response to cisplatin-like drugs in human breast cancer cells probed by vibrational microspectroscopy
10.1039/C5FD00148J
Profiling of human burned bones: oxidising versus reducing conditions
10.1038/s41598-020-80462-3
Beyond metrics and morphology: the potential of FTIR-ATR and chemometrics to estimate age-at-death in human bone
10.1007/s00414-020-02310-3
Polymorphism in Cisplatin Anticancer Drug
10.1021/JP403486Z
Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin
10.3390/pharmaceutics15041205
Vibrational spectroscopy to study ancient Roman funerary practices at the “Hypogeum of the Garlands” (Italy)
10.1038/s41598-022-07689-0
Microplastics ingestion and endocrine disrupting chemicals (EDCs) by breeding seabirds in the east tropical Atlantic: Associations with trophic and foraging proxies (615N and 613C)
10.1016/j.scitotenv.2023.168664
Pd2Spermine as an Alternative Therapeutics for Cisplatin-Resistant Triple-Negative Breast Cancer
10.1021/acs.jmedchem.4c00435
Novel platinum-based anticancer drug: a complete vibrational study
10.1107/S2053229618005843
Response of Osteosarcoma Cell Metabolism to Platinum and Palladium Chelates as Potential New Drugs
10.3390/molecules26164805
Neutrons for Cultural Heritage—Techniques, Sensors, and Detection
10.3390/s20020502
Influence of paternal factors on plastic ingestion and brominated chemical exposure in East Tropical Atlantic Procellariid chicks
10.1016/j.scitotenv.2024.173815
Cellular dynamics as a marker of normal-to-cancer transition in human cells
10.1038/s41598-023-47649-w
Anthropogenic debris ingestion in a tropical seabird community: Insights from taxonomy and foraging distribution
10.1016/j.scitotenv.2023.165437
Water dynamics in human cancer and non-cancer tissues
10.1039/D2CP00621A
Heat-induced Bone Diagenesis Probed by Vibrational Spectroscopy
10.1038/s41598-018-34376-w
Plastisphere assemblages differ from the surrounding bacterial communities in transitional coastal environments
10.1016/j.scitotenv.2023.161703
Metallodrug-Protein Interaction Probed by Synchrotron Terahertz and Neutron Scattering Spectroscopy
10.1016/j.bpj.2021.06.012
Cervical Squamous Cell Carcinoma Diagnosis by FTIR Microspectroscopy
10.3390/molecules29050922
In-Situ Anaerobic Heating of Human Bones Probed by Neutron Diffraction
10.1021/acs.analchem.2c04721
Chemotherapeutic Targets in Osteosarcoma: Insights from Synchrotron-MicroFTIR and Quasi-Elastic Neutron Scattering
10.1021/ACS.JPCB.9B05596
Evaluation of the Cytotoxic Effect of Pd2Spm against Prostate Cancer through Vibrational Microspectroscopies
10.3390/ijms24031888
Breast cancer or surrounding normal tissue? A successful discrimination by FTIR or Raman microspectroscopy
10.1039/D2AN00622G
A New Look into Cancer-A Review on the Contribution of Vibrational Spectroscopy on Early Diagnosis and Surgery Guidance
10.3390/CANCERS13215336
Who's Who? Discrimination of Human Breast Cancer Cell Lines by Raman and FTIR Microspectroscopy
10.3390/CANCERS14020452
Antioxidant Potential of Tamarillo Fruits—Chemical and Infrared Spectroscopy Analysis
10.3390/antiox12020536
A Non-Conventional Platinum Drug against a Non-Small Cell Lung Cancer Line
10.3390/molecules28041698
A New Look into the Mode of Action of Metal-Based Anticancer Drugs
10.3390/molecules25020246