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(Chemical) Bonding is what makes life possible

José Almeida

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Research group
Molecular Synthesis

Position
PhD student

Researcher IDV-6371-2018
Ciência IDC316-5B57-2DBD
I’m a Sustainable Chemistry PhD student and my work is focused on the development of new photosensitizers for photodynamic therapy. Some of the work objectives are: 1) the conjugation of porphyrins and hydroporphyrins with bioactive molecules and enzymatic inhibitors, which could be released in physiological media through a cleavable linker; 2) synthesis of new hydroporphyrins through mild and efficient protocols (e.g., by using microwave irradiation); 3) incorporation of porphyrins and hydroporphyrins in metal-organic frameworks, which would enhance significantly the therapeutic efficiency of PDT.

Representative Publications

Synthesis and coordination studies of 5-(4′-carboxyphenyl)-10,15,20-tris(pentafluorophenyl)porphyrin and its pyrrolidine-fused chlorin derivative
10.1039/C7NJ05165D
1,3-Dipolar cycloadditions with meso-tetraarylchlorins - site selectivity and mixed bisadducts
10.1039/c6qo00771f