Research group
Nanoplatforms for Life
Position
Researcher
Mariana Ferreira is a young Post-Doctoral researcher at REQUIMTE - Nanoplatforms for Life, under the supervision of Dr. Paula Gameiro. Her study is focused on the development of metallocomplexes to bypass some bacterial resistance mechanisms. The work comprises the characterization of complexes of transition metals, the study of interaction of the compounds with membrane mimetic systems, the assessment of biological activity and safety of the compounds. In this context, during the last decade she improved her technical skills of biophysical and biochemical techniques, especially potentiometry (determination of constants of metal complexes), spectroscopy (UV-vis and fluorescence - steady-state, anisotropy, lifetime), SPR and microbiology.
Representative Publications
Data on Laurdan spectroscopic analyses to compare membrane fluidity between susceptible and multidrug-resistant bacteria
10.1016/j.dib.2018.09.106
A fast way to track functional OmpF reconstitution in liposomes: Escherichia coli total lipid extract
10.1016/j.ab.2015.03.026
Evaluation of membrane fluidity of multidrug-resistant isolates of Escherichia coli and Staphylococcus aureus in presence and absence of antibiotics
10.1016/j.jphotobiol.2018.03.002
Fluoroquinolone Metalloantibiotics: A Promising Approach against Methicillin-Resistant Staphylococcus aureus
10.3390/ijerph17093127
The Unusual Aggregation and Fusion Activity of the Antimicrobial Peptide W-BP100 in Anionic Vesicles
10.3390/membranes13020138
Fluoroquinolone Metalloantibiotics to Bypass Antimicrobial Resistance Mechanisms: Decreased Permeation through Porins
10.3390/membranes11010003
Passive Diffusion of Ciprofloxacin and its Metalloantibiotic: A Computational and Experimental study
10.1016/j.jmb.2021.166911
