Research group
Nanoplatforms for Life
Position
Academic Staff
Assistant Professor (PhD Analytical Chemistry), Chemistry Department, FFUP
Research: Development of sustainable automated (micro)fluidic (bio)analytical tools for application, mainly, in environmental, environmental and biomedical areas.
In this context, enzymes are mostly used, whether in solution or on (nano)solid supports, as analytes or reagents.
Has been focused in studying the potential of ionic liquids (ILs) in replacing organic solvents in bioassays, and their impact on the environment. In this sense, there are some studies evaluating the positive effect of ILs on biocatalysis, also in the presence of micelles, keeping in mind their application, particularly in organic syntheses.
Following research in the field of ILs, has been testing the modular synthesis processes of group of uniform materials based on organic salts - GUMBOS and derived nanomaterials, nanoGUMBOS, their special characteristics and their absolute ability to react with proteins, in order to develop sensors for diagnosing wound biomarkers. Also, the synthesis of GUMBOS as active pharmaceutical ingredients, combining anti-inflammatories with antibiotics, or antibiotics from different families.
Microfluidic methodologies are also being developed to evaluate the possible use of synthetic compounds in the treatment of cancer, testing their effect on enzymes linked to this pathology.
The impact of drugs by evaluating their toxic (or inhibitory) effect on enzymes with important biological functions and even in whole cells. To achieve this, it has fundamentally resorted to automation.
Supervision: PhD: 10 (full); 7 (partial - international); Masters: 12 (3 international)
Pos-Doc: 3; Erasmus, short-training, research initiation: 50
Published works: 3 book chapter; 126 peer-reviewed ISI papers, 70 oral communications and 140 posters in scientific conferences
Representative Publications
Automatic evaluation of peroxidase activity using different substrates under a micro sequential injection analysis/lab-on-valve (mu SIA-LOV) format
10.1016/j.microc.2017.05.010
Automated evaluation of pharmaceutically active ionic liquids' (eco)toxicity through the inhibition of human carboxylesterase and Vibrio fischeri
10.1016/j.jhazmat.2013.11.052
Active pharmaceutical ingredients based on salicylate ionic liquids: insights into the evaluation of pharmaceutical profiles
10.1039/c3nj00731f
Evaluation of Ionic Liquids and Ionic Liquids Active Pharmaceutical Ingredients Inhibition in Elastase Enzyme Activity
10.3390/molecules26010200
Development of automatic systems to study the loading and release of anticancer drugs from mesoporous silica nanoparticles
Development of an automated yeast-based spectrophotometric method for toxicity screening: Application to ionic liquids, GUMBOS, and deep eutectic solvents
10.1016/j.chemosphere.2021.130227
Automatic methodologies to perform loading and release assays of anticancer drugs from mesoporous silicon nanoparticles
10.1016/j.talanta.2018.12.025
Combined use of phosphonium-erythrosin B-based nanoGUMBOS, UV-Vis spectroscopy, and chemometrics for discrimination and quantification of proteins
10.1016/j.dyepig.2022.110635
