Research group
Molecular Synthesis
Position
Academic Staff
Paula A. C. Gomes is an Associate Professor, with Habilitation in Chemistry, at the Department of Chemistry and Biochemistry of the Faculty of Sciences of the University of Porto (FCUP), Portugal.
Paula research goals include (i) antimalarial drug rescuing and repurposing, and (ii) antimicrobial peptide-based materials and strategies to fight antibiotic-resistant infections. Paula is also the coordinator of the peptide synthesis core facility in FCUP.
Paula is one of the Chairpersons of the Chemistry in Life Sciences Division of the Portuguese Chemistry Society, the Secretary of the European Peptide Society, and an Associate Member of Division VII – Chemistry and Human Health, of the International Union for Pure and Applied Chemistry.
Representative Publications
Characterization of hLF1-11 immobilization onto chitosan ultrathin films, and its effects on antimicrobial activity
10.1016/j.actbio.2014.02.028
N-cinnamoylation of antimalarial classics: Quinacrine analogues with decreased toxicity and dual-stage activity
10.1002/cmdc.201300459
N-Cinnamoylated chloroquine analogues as dual-stage antimalarial leads
10.1021/jm301654b
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
10.1016/j.ejmech.2012.05.022
Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum
10.1128/AAC.00873-12
Antigenicity modulation upon peptide cyclization: Application to the GH loop of foot-and-mouth disease virus strain C1-Barcelona
10.1016/S0264-410X(01)00047-0
Unravelling a Mechanism of Action for a Cecropin A-Melittin Hybrid Antimicrobial Peptide: The Induced Formation of Multilamellar Lipid Stacks
10.1021/acs.langmuir.7b03639
Synergistic and antibiofilm properties of ocellatin peptides against multidrug-resistant Pseudomonas aeruginosa
10.2217/fmb-2017-0175
Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries
10.3390/molecules22101743
A novel synthetic peptide inspired on Lys49 phospholipase A(2) from Crotalus oreganus abyssus snake venom active against multidrug-resistant clinical isolates
10.1016/j.ejmech.2018.02.055
