Research group
Environmental Chemistry
Position
Researcher
Clara Grosso has a degree in Plant Biology (FCUL, 2004) and a PhD degree in Biotechnology (IST, 2010). From February 2010 to December 2014, she was a Post-Doc researcher (REQUIMTE/LAQV-FFUP and University of Copenhagen (UCPH)). Since 2016, she is assistant researcher at REQUIMTE/LAQV-ISEP. Her field of research focuses on natural products, regarding aspects like extraction optimization, identification of secondary metabolites and assessment of in vitro bioactivities with emphasis on oxidative stress and enzymes related to Alzheimer's disease and depression. Since 2015, she has been PI of four projects/grants: "Sea_4_Brain_Food: Green extraction of marine neuroprotective compounds targeting functional foods for silver generation", funded by REQUIMTE (2017), "Flavonoids for Brain Disorders: Engineering Polymeric Nanoparticles to Improve Drug Delivery", funded by FCT (IF/ 01332/2014/CP1255/CT0001, 2015-2019), "SilverBrain - From sea to brain: Green neuroprotective extracts for nanoencapsulation and functional food production", funded by FEDER and FCT (PTDC/OCE-ETA/30240/2017, 2018-2022) and "#MINDtheMOOD: Exploring NMDA receptors for discovering new fast-acting antidepressants for Treatment-resistant depression" funded by FCT (CEECIND/03436/2020). She is also the responsible investigator of the REQUIMTE team in the CYTED project GEnoPsySEn - Development of genosensors for pharmacogenomic targets in the central nervous system (2023-2026, Rede 223RT0141). Since 2012, she has supervised several undergraduate students, 9 MSc theses (plus 3 ongoing) and one PhD student (ongoing). She authored 66 articles, 11 book chapters, and edited a book published by Springer in 2016. She is also a member of the editorial board of Current Medicinal Chemistry (Bentham) and Processes (MDPI) and is/was guest editor for 4 special issues. She has been an international evaluator for several science foundations. She is reviewer for more than 40 international scientific journals.
Representative Publications
HPLC-DAD analysis and in vitro enzyme inhibition: An integrated approach to predict herbal binary mixture behaviour employing median effect equation
10.1016/j.microc.2014.12.006
Coupling of a High-resolution Monoamine Oxidase-A Inhibitor Assay and HPLC-SPE-NMR for Advanced Bioactivity Profiling of Plant Extracts
10.1002/pca.2393
Seaweeds: new source of MAO-A inhibiting compounds
Functionalized liposomes and phytosomes loading Annona muricata L. aqueous extract: Potential nanoshuttles for brain-delivery of phenolic compounds
10.1016/j.phymed.2018.03.053
Herbal Medicine in Depression: Traditional Medicine to Innovative Drug Delivery. Springer International Publishing, Switzerland
10.1007/978-3-319-14021-6
Multi-Step Subcritical Water Extracts of Fucus vesiculosus L. and Codium tomentosum Stackhouse: Composition, Health-Benefits and Safety
10.3390/pr9050893
Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts
10.3390/nano11030563
Interactions between Ginkgo biloba L. and Scutellaria baicalensis Georgi in multicomponent mixtures towards cholinesterase inhibition and ROS scavenging
10.1016/j.foodres.2020.109857
Phenolic compounds from Jacaranda caroba (Vell.) A. DC.: approaches to neurodegenerative disorders.
Phytochemical compounds with promising biological activities from Ascophyllum nodosum extracts using microwave-assisted extraction
10.1016/j.foodchem.2023.138037
