LAQV REQUIMTE

(Chemical) Bonding is what makes life possible

Paula Gameiro

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351220402589

Research group
Nanoplatforms for Life

Position
Academic Staff

Researcher IDC-3054-2012
Ciência ID3E10-2AAF-86CF
Paula Gameiro research activities are focused on the biophysical and biological study of drugs interaction with biological membranes. The main research goal being the development of new materials and strategies to fight antibiotic-resistant infections.
Paula research goals include (i) use and development of spectroscopic and microscopic techniques to study biological membrane changes related with the mechanism of action/resistance of antibiotics (fluoroquinolone, fluoroquinolone metalloantibiotics and antimicrobial peptides/metallopeptides), (ii) biological and biophysical study of antimicrobial activity, bacteria biofilms, and bacterial membrane fluidity.

Representative Publications

The binding of free and copper-complexed fluoroquinolones to OmpF porins: an experimental and molecular docking study
10.1039/c6ra26466b
Fluoroquinolone-metal complexes: A route to counteract bacterial resistance?
10.1016/j.jinorgbio.2014.05.007
Evaluation of membrane fluidity of multidrug-resistant isolates of Escherichia coli and Staphylococcus aureus in presence and absence of antibiotics
10.1016/j.jphotobiol.2018.03.002
Antibacterial activity of naphthyl derived bis-(3-hydroxy-4-pyridinonate) copper(II) complexes against multidrug-resistant bacteria
10.1016/j.jinorgbio.2019.110704
Intragenic Antimicrobial Peptide Hs02 Hampers the Proliferation of Single- and Dual-Species Biofilms of P. aeruginosa and S. aureus: A Promising Agent for Mitigation of Biofilm-Associated Infections
10.3390/ijms20143604
Cardiolipin and phosphatidylethanolamine role in dibucaine interaction with the mitochondrial membrane
10.1016/j.bbamem.2019.02.011