(Chemical) Bonding is what makes life possible

Hugo Miguel Santos


Research group
(Bio)Chemistry & Omics


Researcher IDJ-7638-2019
Ciência ID2F13-9061-2009
As a researcher, I am passionate about the development of technology-oriented methods to guide medical decisions and therapeutic intervention based on sound principles and less empiric therapy. To achieve such aims, I am most dedicated to the development of interdisciplinary approaches using nano-proteomics, supramolecular separation methods, mass spectrometry (MS) and computational tools for early detection of pathologies and reliable screening in multiple myeloma, neurodegeneration, bladder cancer and renal cell carcinoma (RCC). My research productivity accounts for 87 publications in international peer-review journals, attracting a high number of citations, over 2190, with 23 papers being cited at least 23 times.

Representative Publications

Ultrasonic-assisted extraction and digestion of proteins from solid biopsies followed by peptide sequential extraction hyphenated to MALDI-based profiling holds the promise of distinguishing renal oncocytoma from chromophobe renal cell carcinoma
Snap-heated freeze-free preservation and processing of the urine proteome using the combination of stabilizor-based technology and filter aided sample preparation
Development of a Robust Ultrasonic-Based Sample Treatment To Unravel the Proteome of OCT-Embedded Solid Tumor Biopsies
Label-free protein quantification after ultrafast digestion of complex proteomes using ultrasonic energy and immobilized-trypsin magnetic nanoparticles
A methodological approach based on gold-nanoparticles followed by matrix assisted laser desorption ionization time of flight mass spectrometry for the analysis of urine profiling of knee osteoarthritis