LAQV REQUIMTE

(Chemical) Bonding is what makes life possible

Hugo Miguel Santos

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Research group
(Bio)Chemistry & Omics

Position
Researcher

Researcher IDJ-7638-2019
Ciência ID2F13-9061-2009
As a researcher, I am passionate about the development of technology-oriented methods to guide medical decisions and therapeutic intervention based on sound principles and less empiric therapy. To achieve such aims, I am most dedicated to the development of interdisciplinary approaches using nano-proteomics, supramolecular separation methods, mass spectrometry (MS) and computational tools for early detection of pathologies and reliable screening in multiple myeloma, neurodegeneration, bladder cancer and renal cell carcinoma (RCC). My research productivity accounts for 91 publications in international peer-review journals, attracting a high number of citations, over 2200, with 23 papers being cited at least 23 times.

Representative Publications

Ultrasonic-assisted extraction and digestion of proteins from solid biopsies followed by peptide sequential extraction hyphenated to MALDI-based profiling holds the promise of distinguishing renal oncocytoma from chromophobe renal cell carcinoma
10.1016/j.talanta.2019.120180
Snap-heated freeze-free preservation and processing of the urine proteome using the combination of stabilizor-based technology and filter aided sample preparation
10.1016/j.aca.2019.05.051
Editorial - splicing and alternative splicing
10.1016/j.biocel.2019.06.001
Development of a Robust Ultrasonic-Based Sample Treatment To Unravel the Proteome of OCT-Embedded Solid Tumor Biopsies
10.1021/acs.jproteome.9b00248
Ultrasonic-Based Filter Aided Sample Preparation as the General Method to Sample Preparation in Proteomics
10.1021/acs.analchem.0c01470
Absolute quantitative proteomics using the total protein approach to identify novel clinical immunohistochemical markers in renal neoplasms
10.1186/s12916-021-02071-9
Prescriptomics
10.5584/jiomics.v12i1.211
Role of Hexokinase-1 and LAMP-1 Immunohistochemistry to Differentiate Oncocytoma and Chromophobe Renal Cell Carcinoma from Other Renal Neoplasms
The Hypocholesterolemic Potential of the Edible Algae Fucus vesiculosus: Proteomic and Quantitative PCR Analysis
10.3390/foods12142758
Pathway-guided monitoring of the disease course in bladder cancer with longitudinal urine proteomics
10.1038/s43856-023-00238-4