LAQV REQUIMTE

(Chemical) Bonding is what makes life possible

Manuela Morato

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Research group
Natural Products – Chemistry and Bioactivity

Position
Academic Staff

Researcher IDD-7563-2013
Ciência IDF111-0057-247C
Degree in Pharmaceutical Sciences (1997), PhD in Pharmacology (2004), Faculty of Pharmacy, University of Porto (FFUP). Assistant Professor, Laboratory of Pharmacology, FFUP.
Research: pathophysiology of renin-angiotensin system in cardiovascular and inflammatory diseases. Hypertension, heart failure, diabetes, obesity, renal disease. Inflammatory bowel disease. Clinical and experimental models. Certificated to work with laboratory animals.
Supervisor of 8 PhD students, 10 Master students, and of several undergraduates. PI of 3 research projects and co-PI of 9. Several awards within scientific meetings.
Published 1 book chapter, 5 review papers, 1 letter to the Editor, and 19 original papers in international journals with peer-review.

Representative Publications

Aminosalicylates and COVID-19: Facts or Coincidences?
10.1053/j.gastro.2020.05.092
Experimental and clinical evidence of endothelial dysfunction in inflammatory bowel disease
10.1111/j.1440-1746.2010.06455.x
Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease
10.1093/ibd/izaa249
Diabetes downregulates renal adenosine A(2A) receptors in an experimental model of hypertension
10.1371/journal.pone.0217552
Association of myeloperoxidase levels with cardiometabolic factors and renal function in prepubertal children
10.1111/eci.12564
Attenuated Aortic Vasodilation and Sympathetic Prejunctional Facilitation in Epinephrine-Deficient Mice: Selective Impairment of beta(2)-Adrenoceptor Responses
10.1124/jpet.114.217281
Activation of adenosine receptors improves renal antioxidant status in diabetic Wistar but not SHR rats
10.3109/03009734.2013.851748
Diabetes-induced increase of renal medullary hydrogen peroxide and urinary angiotensinogen is similar in normotensive and hypertensive rats
10.1016/j.lfs.2014.05.011
Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors
10.1152/ajprenal.00285.2012
Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein
10.1016/j.ejphar.2010.10.075
Does Chronic Pain Alter the Normal Interaction Between Cardiovascular and Pain Regulatory Systems? Pain Modulation in the Hypertensive-Monoarthritic Rat
10.1016/j.jpain.2010.06.009
Renal effects of adenosine on diabetic Wistar and SHR rats
Effect of 2-chloroadenosine on sodium and potassium excretion in diabetic Wistar and SHR rats
Endogenous and exogenous adenosine and structural alterations in diabetic nephropathy: a possible role of the renin-angiotensin system?