(Chemical) Bonding is what makes life possible

Manuela Morato


Research group
Natural Products – Chemistry and Bioactivity

Academic Staff

Researcher IDD-7563-2013
Ciência IDF111-0057-247C
Degree in Pharmaceutical Sciences (1997), PhD in Pharmacology (2004), Faculty of Pharmacy, University of Porto (FFUP). Assistant Professor, Laboratory of Pharmacology, FFUP.
Research: pathophysiology of renin-angiotensin system in cardiovascular and inflammatory diseases. Hypertension, heart failure, diabetes, obesity, renal disease. Inflammatory bowel disease. Clinical and experimental models. Certificated to work with laboratory animals.
Supervisor of 8 PhD students, 10 Master students, and of several undergraduates. PI of 3 research projects and co-PI of 9. Several awards within scientific meetings.
Published 1 book chapter, 5 review papers, 1 letter to the Editor, and 19 original papers in international journals with peer-review.

Representative Publications

Association of myeloperoxidase levels with cardiometabolic factors and renal function in prepubertal children
Attenuated Aortic Vasodilation and Sympathetic Prejunctional Facilitation in Epinephrine-Deficient Mice: Selective Impairment of beta(2)-Adrenoceptor Responses
Diabetes-induced increase of renal medullary hydrogen peroxide and urinary angiotensinogen is similar in normotensive and hypertensive rats
Activation of adenosine receptors improves renal antioxidant status in diabetic Wistar but not SHR rats
Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors
Functional crosstalk of prejunctional receptors on the modulation of noradrenaline release in mesenteric vessels: A differential study of artery and vein
Does Chronic Pain Alter the Normal Interaction Between Cardiovascular and Pain Regulatory Systems? Pain Modulation in the Hypertensive-Monoarthritic Rat
Renal effects of adenosine on diabetic Wistar and SHR rats
Endogenous and exogenous adenosine and structural alterations in diabetic nephropathy: a possible role of the renin-angiotensin system?
Effect of 2-chloroadenosine on sodium and potassium excretion in diabetic Wistar and SHR rats
Diabetes downregulates renal adenosine A(2A) receptors in an experimental model of hypertension
Experimental and clinical evidence of endothelial dysfunction in inflammatory bowel disease
Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease
Aminosalicylates and COVID-19: Facts or Coincidences?