LAQV REQUIMTE

(Chemical) Bonding is what makes life possible

Nelson Gomes

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Research group
Chemistry and Bioactivity

Position
Researcher

Researcher IDS-5420-2016
Ciência IDDC11-EFB8-2085
Nelson Gomes (PharmD, PhD) graduated in Pharmaceutical Sciences from the University of Coimbra in 2008, and obtained his PhD in Biomedical Sciences from the University of Porto. In 2014, he moved to Kasetsart University (Thailand) to continue his work on the discovery of bioactives from marine fungi. Currently, he serves as a research associate at the Associated Laboratory for Green Chemistry (LAQV) of the Network of Chemistry and Technology (REQUIMTE) serving also as an invited Assistant Professor at the University Institute of Health Sciences (IUCS-CESPU) and as a visiting Professor at Kasetsart University in Bangkok, Thailand.
In 2016, he initiated a new research line at REQUIMTE/LAQV focusing on the therapeutic value of plants from Western Africa and Southeast Asia through an ethnopharmacological approach. His primary objective is to discover new preclinical candidates for enriching developmental pipelines in anti-inflammatory, neuroprotective, and neuromodulatory therapy, but also to validate the ethnomedicinal use of plants and to identify new plant-derived ingredients to be included in herbal supplements and drugs. Additionally, his research extends to elucidating toxic mechanisms and identifying toxic constituents from psychoactive and psychedelic plants. His publication record demonstrates that his main expertise lies in the chemical characterization, isolation, and structure elucidation of natural products using techniques such as Nuclear Magnetic Resonance, High-Resolution Mass Spectrometry, and X-ray crystallography.
Author or co-author of 46 articles in international peer-reviewed journals and 2 book chapters, in the scientific domains of Chemistry, "Drug Discovery" and Ethnopharmacology. Nelson G. M. Gomes presented his research (more than 40 oral or panel presentations) in several national and international conferences (China, Germany, Indonesia, Japan, Portugal, Spain, Thailand and Turkey).

Representative Publications

Anti-inflammatory properties of the stem bark from the herbal drug Vitex peduncularis Wall. ex Schauer and characterization of its polyphenolic profile
10.1016/j.fct.2017.05.020
Hybrid MS/NMR methods on the prioritization of natural products: Applications in drug discovery
10.1016/j.jpba.2017.07.035
Plants with Neurobiological Activity as Potential Targets for Drug Discovery
10.1016/j.pnpbp.2009.07.033
Leaves and stem bark from Allophylus africanus P. Beauv.: An approach to anti-inflammatory properties and characterization of their flavonoid profile
10.1016/j.fct.2018.05.045
Antibacterial and antibiofilm activities of tryptoquivalines and meroditerpenes isolated from the marine-derived fungi Neosartorya paulistensis, N. laciniosa, N. tsunodae, and the soil fungi N. fischeri and N. siamensis.
10.3390/md12020822
Can Some Marine-Derived Fungal Metabolites Become Actual Anticancer Agents?
10.3390/md13063950
Marine-Derived Anticancer Agents: Clinical Benefits, Innovative Mechanisms, and New Targets
10.3390/md17060329
Medicinal plants utilized in Thai Traditional Medicine for diabetes treatment: Ethnobotanical surveys, scientific evidence and phytochemicals
10.1016/j.jep.2020.113177
Anti-inflammatory effects of naringenin 8-sulphonate from Parinari excelsa Sabine stem bark and its semi-synthetic derivatives
10.1016/j.bioorg.2023.106614
Valorisation of kitul, an overlooked food plant: Phenolic profiling of fruits and inflorescences and assessment of their effects on diabetes-related targets
10.1016/j.foodchem.2020.128323
Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects
10.3390/ph14020116
Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact
10.3390/ph13110334
Inhibition of proinflammatory enzymes and attenuation of IL-6 in LPS-challenged RAW 264.7 macrophages substantiates the ethnomedicinal use of the herbal drug Homalium bhamoense cubitt & W.W.Sm
10.3390/ijms21072421