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LAQV researchers synthesized molecules to treat different types of cancer

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Anthony Burke and Carolina Marques, researchers of the Molecular Synthesis Group of LAQV at the University of Évora, synthesized small molecules with the potential to treat several types of cancer, including diffuse large B-cell lymphoma.

Lymphomas are among the most difficult cancers to treat. One promising treatment option can pass through the use of these molecules, which were synthesized using sustainable chemical methods with metallic catalysts.

Additionally to its high antitumor activity, the molecules “showed inhibitory activity of one enzyme, butyrylcholinesterase, that participates in the progression of Alzheimer’s disease”, highlights Anthony Burke.

The work, developed in collaboration with research centers from Switzerland and Spain, is already patented. LAQV researchers are currently working on the identification of molecular targets of these molecules to improve their structural properties and increase their pharmacological efficacy. “Future studies include preclinical and in vivo studies”, said Anthony Burke.

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